Today we are seeing the ability to filibuster Supreme Court justices in the Senate disappear, the so-called "nuclear option". That was easy. Actually, the decision by Mitch McConnell last February not to allow the Senate to consider any nominee of President Obama, no matter how moderate, was the real nuclear option, in terms of momentousness, but the name was already taken.
Given the continued erosion of the comity of the Senate over recent decades, we are better off dispensing with the supermajority requirement and possibly other Senate prerogatives (judicial holds) which only function well within a spirit of cooperation. The sooner the system falls under its own weight, the sooner we may be able to achieve comprehensive reform of the federal government, including electoral reform. That can only happen if Democrats gain substantial power at the national level, which only happens if there is strong negative reaction to Trump and the Republicans because for Republicans, the current system is working just fine, thank you.